脆性位点：因生长缓慢而断裂
Fragile sites: breaking up over a slowdown.
作者信息
Cimprich Karlene A
机构信息
Stanford University, Department of Molecular Pharmacology, Stanford, CA 94305-5174, USA.
出版信息
Curr Biol. 2003 Mar 18;13(6):R231-3. doi: 10.1016/s0960-9822(03)00158-1.
Abstract
Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.
摘要
常见脆性位点是人类基因组中的特定区域，在复制应激条件下特别容易发生基因组不稳定。最近的数据表明，这些位点依赖于检查点激酶ATR来维持其稳定性。
Zotero 插件