Terry Kathryn L, Titus-Ernstoff Linda, Garner Elizabeth O, Vitonis Allison F, Cramer Daniel W
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2003 Mar;12(3):187-90.
Aromatic hydrocarbon hydroxylase (CYP1A1) is involved in the metabolism of many substrates and the subject of cancer studies. This study examined the association between two polymorphic variants of CYP1A1 and ovarian cancer risk. The frequencies of the Msp1 and Ile/Val variants of CYP1A1 were determined in 445 ovarian cancer cases and 472 general population controls in New England. Overall relative risks were calculated as well as those within subgroups of various exposures. There was no increased risk for ovarian cancer associated with possession of either the Msp1 or Ile/Val polymorphism of CYP1A1. Elevated risk for ovarian cancer was found in those who carried an Ile/Val variant and who consumed more than median levels of caffeine (risk ratio = 2.69; 95% confidence interval, 1.18-6.18). No variation by histological type of ovarian cancer was observed. Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered.
芳香烃羟化酶（CYP1A1）参与多种底物的代谢，是癌症研究的对象。本研究检测了CYP1A1的两种多态性变体与卵巢癌风险之间的关联。在新英格兰地区的445例卵巢癌病例和472例一般人群对照中确定了CYP1A1的Msp1和Ile/Val变体的频率。计算了总体相对风险以及不同暴露亚组中的相对风险。CYP1A1的Msp1或Ile/Val多态性与卵巢癌风险增加无关。在携带Ile/Val变体且咖啡因摄入量超过中位数水平的人群中发现卵巢癌风险升高（风险比=2.69；95%置信区间，1.18 - 6.18）。未观察到卵巢癌组织学类型的差异。CYP1A1的多态性变体与咖啡因之间可能存在显著相互作用，这可以解释在未考虑基因型时咖啡因与卵巢癌之间微弱或不一致的关联。
