硼酸化合物作为潜在的药物制剂。

Boronic acid compounds as potential pharmaceutical agents.

作者信息

Yang Wenqian, Gao Xingming, Wang Binghe

机构信息

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA.

出版信息

Med Res Rev. 2003 May;23(3):346-68. doi: 10.1002/med.10043.

DOI:10.1002/med.10043

PMID:12647314

Abstract

Boronic acid compounds have been used, because of their unique structural features, for the development of potent enzyme inhibitors, boron neutron capture agents for cancer therapy, and as antibody mimics that recognize biologically important saccharides. Consequently, there has been a surge of interests in boronic acid compounds. This study reviews the recent development in this area during the last six years.

摘要

硼酸化合物因其独特的结构特征，已被用于开发强效酶抑制剂、用于癌症治疗的硼中子俘获剂以及作为识别具有生物学重要性的糖类的抗体模拟物。因此，人们对硼酸化合物的兴趣激增。本研究回顾了过去六年该领域的最新进展。