Puzyński Stanisław
Psychiatr Pol. 2002 Nov-Dec;36(6 Suppl):53-61.
The introduction of anticonvulsants to the treatment of recurring affective disorders, has significantly broadened the possibilities of helping the ill, especially in the prophylaxis of recurring symptoms of bipolar affective disorders. Carbamazepine and valproate (probably also lamotrigine) are a valuable alternative of Lithium Carbonate. The application of anticonvulsants requires strict rule regiment, which includes: gradual dose increase (especially in lamotrigine), gradual dose reduction when planning ending of the therapy, drug blood-level monitoring, liver action monitoring, haemopoietic system monitoring, in the case of the appearance of flu-like symptoms and skin changes--withdrawal of the drug. In simultaneous application of other drugs (e.g. psychotropic), probable interactions should be considered.
抗惊厥药用于复发性情感障碍的治疗，显著拓宽了帮助患者的可能性，尤其是在双相情感障碍复发症状的预防方面。卡马西平和丙戊酸盐（可能还有拉莫三嗪）是碳酸锂的有价值替代药物。抗惊厥药的应用需要严格的规则制度，包括：逐渐增加剂量（尤其是拉莫三嗪）、计划结束治疗时逐渐减少剂量、监测药物血药浓度、监测肝脏功能、监测造血系统，出现流感样症状和皮肤变化时停药。同时使用其他药物（如精神药物）时，应考虑可能的相互作用。
