Rabinowitz Peter M, Poljak Alex
Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA.
J Gen Intern Med. 2003 Mar;18(3):222-7. doi: 10.1046/j.1525-1497.2003.11101.x.
Rapid developments in genomic and proteomic testing promise to impact the way in which clinicians assess disease risk and drug selection in their patients. Because most diseases result from host-environment interactions, however, primary care providers will need to avoid the trap of biological determinism by examining the important role of environmental factors in their clinical assessments and interventions. This article discusses the application of host-environment concepts to recent developments in the areas of genomics and proteomics.
基因组学和蛋白质组学检测的快速发展有望影响临床医生评估患者疾病风险和选择药物的方式。然而，由于大多数疾病是由宿主与环境的相互作用引起的，初级保健提供者需要通过审视环境因素在其临床评估和干预中的重要作用，避免陷入生物决定论的陷阱。本文讨论了宿主 - 环境概念在基因组学和蛋白质组学领域最新发展中的应用。
