Bindal Rajesh, Goodman Julius M, Kawasaki Aki, Purvin Valerie, Kuzma Benjamin
Department of Neurosurgery, Neuroophthalmology and Neuroradiology Clarian Health Methodist Hospital, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Surg Neurol. 2003 Feb;59(2):87-92; discussion 92. doi: 10.1016/s0090-3019(02)00995-3.
This study was undertaken to determine the natural history of untreated skull base meningiomas. Although there are reports on the natural history of meningiomas, most series contain only a few cases of meningiomas involving the skull base. Natural history information is important when recommending treatment and evaluating results.
The case records and imaging studies of 40 patients with skull base meningiomas from a single practice were reviewed. These patients either did not receive treatment or there was a long delay from the onset of symptoms to the initiation of treatment.
Skull base meningiomas may be very indolent tumors. Patients with these tumors have lived long, comfortable, and relatively productive lives without treatment or with delayed treatment. Impairment may be much less than imaging studies would suggest.
The authors are not advocating that skull base meningiomas not receive treatment. However, their unique experience with this group of patients provides convincing evidence that the indolent behavior of some skull base meningiomas must be considered when recommending various surgical and radiation procedures and interpreting their results in relationship to the functional outcome of the patient.
本研究旨在确定未经治疗的颅底脑膜瘤的自然病史。尽管有关于脑膜瘤自然病史的报道，但大多数系列研究仅包含少数累及颅底的脑膜瘤病例。在推荐治疗方法和评估结果时，自然病史信息很重要。
回顾了来自单一医疗机构的40例颅底脑膜瘤患者的病例记录和影像学研究。这些患者要么未接受治疗，要么从症状出现到开始治疗有很长的延迟。
颅底脑膜瘤可能是生长非常缓慢的肿瘤。患有这些肿瘤的患者在未接受治疗或延迟治疗的情况下，长期过着舒适且相对有成效的生活。功能损害可能远小于影像学研究所示。
作者并非主张颅底脑膜瘤不接受治疗。然而，他们对这组患者的独特经验提供了令人信服的证据，即在推荐各种手术和放射治疗方法并根据患者的功能结果解释其结果时，必须考虑某些颅底脑膜瘤生长缓慢的特性。
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