血清糖皮质激素调节激酶1（SGK1）和钠/氢交换调节因子2（NHERF2）在调节钠氢交换体3（NHE3）中的协同作用。
Concerted roles of SGK1 and the Na+/H+ exchanger regulatory factor 2 (NHERF2) in regulation of NHE3.
作者信息
Yun C Chris
机构信息
Division of Digestive Disease, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Cell Physiol Biochem. 2003;13(1):29-40. doi: 10.1159/000070247.
Abstract
Na+/H+ exchanger regulatory factors, NHERF1 and NHERF2, are structurally related proteins and highly expressed in epithelial cells. These proteins are initially identified as accessory proteins in the regulation of Na+/H+ exchanger isoform 3, NHE3. In addition to regulation of NHE3, recent studies demonstrate the importance of NHERF1 and NHERF2 in recycling and localization of membrane receptors, ion channels and transporters. Recent studies show that serum- and glucocorticoid-induced kinase 1 (SGK1) specifically interacts with NHERF2 but not with NHERF1, adding to the growing number of differences between the two proteins. The association of SGK1 with NHERF2 is necessary for stimulation of NHE3 activity by glucocorticoids. In addition, SGK1 together with NHERF2 stimulates the K+ channel ROMK1, suggesting a broader role of SGK1 in regulation of ion transport.
摘要
钠/氢交换调节因子NHERF1和NHERF2是结构相关蛋白，在上皮细胞中高度表达。这些蛋白最初被鉴定为调节钠/氢交换异构体3（NHE3）的辅助蛋白。除了调节NHE3外，最近的研究表明NHERF1和NHERF2在膜受体、离子通道和转运体的再循环和定位中具有重要作用。最近的研究表明，血清和糖皮质激素诱导激酶1（SGK1）与NHERF2特异性相互作用，而不与NHERF1相互作用，这增加了这两种蛋白之间越来越多的差异。SGK1与NHERF2的结合是糖皮质激素刺激NHE3活性所必需的。此外，SGK1与NHERF2一起刺激钾通道ROMK1，表明SGK1在离子转运调节中具有更广泛的作用。
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