Zheng Bin, Wen Jin-Kun, Han Mei
Department of Biochemistry, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017.
Sheng Li Ke Xue Jin Zhan. 2002 Oct;33(4):305-8.
LIM Proteins contain one or more LIM domains. Proteins of this family capable of interacting with many types of proteins have been identified including structural protein, kinase, and several classes of transcription factors. These interactions have been discovered to display important roles in a variety of fundamental processes including transcriptional regulation, development of cell types and organization of the cytoskeleton. This article reviews recent advances in the characterization of members of the LIM protein family, their biology roles, LIM domain binding protein and the function in heart development.
LIM蛋白含有一个或多个LIM结构域。已鉴定出该家族中能够与多种类型蛋白质相互作用的蛋白质，包括结构蛋白、激酶和几类转录因子。已发现这些相互作用在多种基本过程中发挥重要作用，包括转录调控、细胞类型发育和细胞骨架组织。本文综述了LIM蛋白家族成员的表征、其生物学作用、LIM结构域结合蛋白以及在心脏发育中的功能的最新进展。
