Fuse A, Sato T
National Institute of Infectious Diseases, Tokyo, Japan.
J Gravit Physiol. 2001 Jul;8(1):P63-4.
It is reported that the stay in the space develops anemia, thrombocytopenia, and altered function and structure of red blood cell. The mechanism of these abnormalities was not clarified yet. Therefore, it is necessary to elucidate the mechanism of the effect of the gravity change on the thrombocytopoiesis, which plays the important role for the hemostasis, using animal models. The cloning of thrombopoietin (TPO), followed by the analysis of TPO and c-mpl (its cellular receptor) knockout mice confirmed its role as the primary regulator of thrombopoiesis. TPO has been shown to stimulate both megakaryocyte colony growth from marrow progenitor cells and the maturation of immature megakaryocyte to form functional platelet. This process includes the massive cytoskeletal rearrangement, such as proplatelet formation and fragmentation of proplatelet. In this study we have focused on the thrombopoiesis in mice those were exposed to gravity change by parabolic flight (PF).
据报道，在太空停留会引发贫血、血小板减少以及红细胞功能和结构的改变。这些异常现象的机制尚未阐明。因此，有必要利用动物模型阐明重力变化对血小板生成（其在止血过程中起重要作用）的影响机制。血小板生成素（TPO）的克隆，以及随后对TPO和c-mpl（其细胞受体）基因敲除小鼠的分析，证实了其作为血小板生成主要调节因子的作用。TPO已被证明既能刺激骨髓祖细胞的巨核细胞集落生长，又能促进未成熟巨核细胞成熟以形成功能性血小板。这个过程包括大量细胞骨架重排，如前血小板形成和前血小板片段化。在本研究中，我们聚焦于通过抛物线飞行（PF）暴露于重力变化的小鼠的血小板生成。
