Simon G, Pamnani M B, Overbeck H W
Proc Soc Exp Biol Med. 1976 May;152(1):122-5. doi: 10.3181/00379727-152-39341.
Femoral vein (FV) pressure-volume relationships were measured in vitro in 14 dogs with chronic (more than 4 weeks), one-kidney perinephritic hypertension and in 13 unilaterally nephrectomized normotensive control dogs. Segments of FV were also examined histologically and analyzed for their water and electrolyte contents. Compared to controls: (I) the FV pressure-volume curves of hypertensive dogs were shifted toward the pressure axis (P is less than 0.05); (ii) calcaulated vagous compliance in the pressure range of 0-15 mm Hg was decreased (P is less than 0.05); and (iii) the water and sodium contents of vwins from hypertensive dogs were increased (P is less than 0.05). Histological examination of the FV from hypertensive and control dogs did not reveal significant differences. The findings indicate that the decreases in venous compliance that we have previously observed in the early stages (less than 4 weeks) of perinephritic hypertension in dogs persist into the chronic stage of hypertension. Venous wall "edema" may account for the decreased venous compliance in this form of hypertension.
在14只患有慢性（超过4周）单肾肾周炎高血压的犬以及13只单侧肾切除的正常血压对照犬身上，体外测量了股静脉（FV）的压力-容积关系。还对FV节段进行了组织学检查，并分析了其水和电解质含量。与对照组相比：（I）高血压犬的FV压力-容积曲线向压力轴偏移（P<0.05）；（ii）在0-15 mmHg压力范围内计算出的静脉顺应性降低（P<0.05）；（iii）高血压犬静脉的水和钠含量增加（P<0.05）。对高血压犬和对照犬的FV进行组织学检查未发现显著差异。这些发现表明，我们之前在犬肾周炎高血压早期阶段（少于4周）观察到的静脉顺应性降低在高血压慢性阶段持续存在。静脉壁“水肿”可能是这种高血压形式中静脉顺应性降低的原因。
