Ammonia formation from glutamine isomers by nonacidotic and acidotic perfused rat kidneys.
作者信息
Welbourne T C
出版信息
Proc Soc Exp Biol Med. 1976 May;152(1):64-6. doi: 10.3181/00379727-152-39329.
PMID:1265082
Abstract
The following points summarize these findings: (i) there are 2 glutamine utilizing enzyme systems in the rat kidney; (ii) the cytoplasmic glutamyltransferase system hydrolyzes either glutamine isomer while the mitochondrial localized glutaminase 1 is specific for the L-isomer; (iii) the cytoplasmic pathway contributes 70% of the total renal ammonia production in the normal kidney; (iv) chronic metabolic acidosis results in a 20-fold activation of the mitochondrial glutaminase 1 pathway.
摘要
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