Bollini A, Hernández G, Bravo Luna M, Cinara L, Rasia M
Departmento de Ciencias Fisiológicas, Biofísica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
Clin Hemorheol Microcirc. 2003;28(2):99-105.
The objective of this study was to emphasise the potential power of simple and inexpensive haemorheological tests as predictors of hypertensive gestational disorders through a retrospective study. Blood samples of 195 primigravids with gestational age 18-23 weeks were studied. For data processing pregnant women were allocated into 3 groups, based on difference of SBP and DBP values measured at first and last consultation, and presence of proteinuria and oedema: Normotensive pregnants (n=149), hypertensive pregnants; n=26 and preeclamptic pregnants; n=20. Whole blood viscosity, plasma viscosity, erythrocyte rigidity and aggregability, haemoglobin, hematocrit, total protein, albumin and fibrinogen were assayed. Increased relative viscosity (eta(r)) (p<0.01), decreased erythrocyte deformability (p<0.05), lower O(2) release (p<0.01) and birth weight (p<0.01), showed a negative correlation with filterability index in preeclamptics. There was a decrease of erythrocyte deformability in hypertensive women. Erythrocyte deformability and blood viscosity could be an early indicator in preeclamptics, and erythrocyte deformability in hypertensive ones, therefore they could be considered alert factors in order to decide a thorough control in these patients to prevent further complications.
本研究的目的是通过一项回顾性研究，强调简单且廉价的血液流变学检测作为妊娠期高血压疾病预测指标的潜在作用。对195例孕龄为18 - 23周的初产妇的血样进行了研究。为了进行数据处理，根据首次和末次会诊时测量的收缩压和舒张压值的差异以及蛋白尿和水肿的情况，将孕妇分为3组：血压正常的孕妇（n = 149）、高血压孕妇（n = 26）和先兆子痫孕妇（n = 20）。检测了全血粘度、血浆粘度、红细胞刚性和聚集性、血红蛋白、血细胞比容、总蛋白、白蛋白和纤维蛋白原。先兆子痫患者中相对粘度（η(r)）升高（p < 0.01）、红细胞变形性降低（p < 0.05）、氧释放降低（p < 0.01）和出生体重降低（p < 0.01）与滤过指数呈负相关。高血压女性的红细胞变形性降低。红细胞变形性和血液粘度可能是先兆子痫的早期指标，而红细胞变形性是高血压患者的早期指标，因此，为了对这些患者进行全面控制以预防进一步并发症，可将它们视为警示因素。
