Rust G S, Thompson C J, Minor P, Davis-Mitchell W, Holloway K, Murray V
National Center for Primary Care, Morehouse School of Medicine, Atlanta, Georgia 30310, USA.
J Natl Med Assoc. 2001 Apr;93(4):139-48.
We sought to determine whether breastfeeding (yes/no) or its duration protects against the development of childhood asthma, its severity or age of onset. We conducted a secondary analysis of youth files of the National Health and Nutrition Examination Survey III (1988-94), and reviewed data from 6,783 children age 2 months to 6 years (3,316 breastfed), excluding children with a history of low birth weight or treatment in a neonatal intensive care unit. Study participants were breastfed an average of 157 days. The average age at onset of asthma was 14.3 months. In the logistic regression model, "ever breast-fed" was not a significant protective factor for developing asthma. Significant predictive factors were the mother's age at child's birth (beta = -0.08, p < 0.01), and a parent having asthma or hayfever (beta = 0.46, p < 0.01). In the linear regression model, the duration of breastfeeding was not a predictor for age at onset of asthma (beta = 0.01, p = 0.53). Only maternal smoking during pregnancy was a significant predictor of age at onset of asthma (beta = -7.59, p < 0.01). Breastfeeding does not appear to prevent asthma, delay its onset, or reduce its severity. However, breastfeeding is still recommended for its many other benefits.
我们试图确定母乳喂养(是/否)及其持续时间是否能预防儿童哮喘的发生、严重程度或发病年龄。我们对第三次全国健康和营养检查调查(1988 - 1994年)的青少年档案进行了二次分析,并审查了6783名年龄在2个月至6岁儿童(3316名母乳喂养)的数据,排除了有低出生体重史或在新生儿重症监护病房接受治疗的儿童。研究参与者平均母乳喂养157天。哮喘发病的平均年龄为14.3个月。在逻辑回归模型中,“曾经母乳喂养”不是患哮喘的显著保护因素。显著的预测因素是母亲生育时的年龄(β = -0.08,p < 0.01),以及父母一方患有哮喘或花粉热(β = 0.46,p < 0.01)。在线性回归模型中,母乳喂养的持续时间不是哮喘发病年龄的预测因素(β = 0.01,p = 0.53)。只有孕期母亲吸烟是哮喘发病年龄的显著预测因素(β = -7.59,p < 0.01)。母乳喂养似乎不能预防哮喘、延迟其发病或减轻其严重程度。然而,鉴于母乳喂养还有许多其他益处,仍建议进行母乳喂养。