Dong Jingyu, Chong Yap-Yee, Meyerson Howard J
Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.
Arch Pathol Lab Med. 2003 Mar;127(3):e119-22. doi: 10.5858/2003-127-e119-HTLARO.
Hepatosplenic T-cell lymphoma is an uncommon neoplasm characterized by a lymphoid infiltrate within the sinusoids of the liver, spleen, and bone marrow, without significant nodal involvement. The majority of cases express the gammadelta T-cell receptor and are associated with an isochromosome 7q cytogenetic abnormality. Recently, a small number of cases have been reported that express the alphabeta T-cell receptor. Here, we report our findings of a case of an S100-positive hepatosplenic alphabeta T-cell lymphoma in a 20-year-old woman who presented with pancytopenia and hepatosplenomegaly. The case adds to the growing literature of hepatosplenic alphabeta T-cell lymphomas.
肝脾T细胞淋巴瘤是一种罕见的肿瘤，其特征为肝脏、脾脏和骨髓的血窦内有淋巴细胞浸润，无明显淋巴结受累。大多数病例表达γδ T细胞受体，并与7号染色体长臂等臂染色体细胞遗传学异常相关。最近，有少数病例报告表达αβ T细胞受体。在此，我们报告了一例20岁女性的S100阳性肝脾αβ T细胞淋巴瘤病例，该患者表现为全血细胞减少和肝脾肿大。该病例增加了有关肝脾αβ T细胞淋巴瘤的文献报道。
