Dimashkieh Haytham, Choe Jong, Mutema George
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Arch Pathol Lab Med. 2003 Mar;127(3):e135-8. doi: 10.5858/2003-127-e135-RMCARO.
Renal medullary carcinoma is a recently described aggressive neoplasm of the kidney. With the exception of 2 patients, all other reported cases have been associated with sickle cell hemoglobinopathies, mainly sickle cell trait and hemoglobin SC disease. Renal medullary carcinoma is a highly malignant tumor with evidence of angiolymphatic and distant metastasis at the time of diagnosis. No specific genetic abnormality has been identified in this neoplasm despite its close association with a genetic disease. We describe 2 cases of renal medullary carcinoma, one associated with hemoglobin SC disease, and the other with what we believe to be the first reported case associated with sickle cell disease.
肾髓质癌是一种最近才被描述的侵袭性肾脏肿瘤。除2例患者外，所有其他报告病例均与镰状细胞血红蛋白病相关，主要是镰状细胞性状和血红蛋白SC病。肾髓质癌是一种高度恶性肿瘤，在诊断时就有血管淋巴管和远处转移的证据。尽管该肿瘤与一种遗传性疾病密切相关，但尚未发现其有特定的基因异常。我们描述了2例肾髓质癌，1例与血红蛋白SC病相关，另1例我们认为是首例与镰状细胞病相关的报告病例。
