Padilla Carmencita, Nishiyama Kaoru, Shirakawa Taku, Matsuo Masafumi
Department of Pediatrics, College of Medicine-Philippine General Hospital, University of the Philippines Manila, Philippines.
Pediatr Int. 2003 Feb;45(1):10-5. doi: 10.1046/j.1442-200x.2003.01676.x.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency has increased prevalence rates in tropical Africa, tropical and subtropical Asia and some parts of the Mediterranean. Earlier studies on G6PD deficiency in the Philippines have shown prevalence rates of 4.5% to 25.7%.
In the present study, 3278 male newborns were screened for G6PD deficiency using the modified formazan method, a simple screening procedure affordable in the setting of a developing country. Subjects with positive screening results were recalled for confirmatory testing using a commercial assay kit for quantitative enzyme determination.
Of the 3278 boys studied, 186 revealed positive screening results. Of the 186, 65 boys had confirmatory testing. Of these 65 boys, 45 were confirmed to have G6PD deficiency and 20 had normal results. This study reveals an incidence of G6PD deficiency of 3.9% among male Filipinos.
This study recommends the inclusion of G6PD deficiency in the panel of disorders for newborn screening among Filipino newborns.
葡萄糖-6-磷酸脱氢酶（G6PD）缺乏症在热带非洲、热带和亚热带亚洲以及地中海部分地区的患病率有所上升。早期对菲律宾G6PD缺乏症的研究显示患病率为4.5%至25.7%。
在本研究中，采用改良的甲臜法对3278名男性新生儿进行G6PD缺乏症筛查，这是一种在发展中国家环境下经济实惠的简单筛查程序。筛查结果呈阳性的受试者被召回，使用商业检测试剂盒进行定量酶测定以进行确诊检测。
在研究的3278名男孩中，186名筛查结果呈阳性。在这186名中，65名男孩进行了确诊检测。在这65名男孩中，45名被确诊为G6PD缺乏症，20名结果正常。本研究显示菲律宾男性中G6PD缺乏症的发病率为3.9%。
本研究建议将G6PD缺乏症纳入菲律宾新生儿疾病筛查项目中。
