Fan Wen-Hong, Zhan Qi-Min
National Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, 100021, P.R. China.
Ai Zheng. 2003 Mar;22(3):331-5.
BRCA1 is a 220kDa nuclear protein with multiple functional domains. It interacts directly or indirectly with a variety of important proteins, including oncogene proteins (c-myc, E2F), tumor suppressor proteins (p53, RB, BRCA2), DNA damage repair proteins (RAD50, RAD51), cell-cycle regulators (cyclin, CDK), transcriptional regulators (RNA polymerase II) and others related to the important biological events. BRCA1 is likely to play an important role in the maintenance of genomic stability through its activities in cell-cycle progression, DNA damage repair, transcriptional regulation, and apoptosis. Here, the authors provided a review of the biochemistry structure of BRCA1 as well as its role in maintaining the genomic stability.
BRCA1是一种具有多个功能域的220kDa核蛋白。它直接或间接与多种重要蛋白质相互作用，包括癌基因蛋白（c-myc、E2F）、肿瘤抑制蛋白（p53、RB、BRCA2）、DNA损伤修复蛋白（RAD50、RAD51）、细胞周期调节因子（细胞周期蛋白、细胞周期蛋白依赖性激酶）、转录调节因子（RNA聚合酶II）以及其他与重要生物学事件相关的蛋白。BRCA1可能通过其在细胞周期进程、DNA损伤修复、转录调控和细胞凋亡中的活动，在维持基因组稳定性方面发挥重要作用。在此，作者对BRCA1的生物化学结构及其在维持基因组稳定性中的作用进行了综述。
