Kono Yoshiki, Sugiyama Kazuhisa, Ishida Kyoko, Yamamoto Tetsuya, Kitazawa Yoshiaki
Department of Ophthalmology, Gifu University School of Medicine, Gifu, Japan.
Am J Ophthalmol. 2003 Apr;135(4):499-503. doi: 10.1016/s0002-9394(02)02056-1.
To study the characteristics of visual field progression in patients with normal-tension glaucoma (NTG) with optic disk hemorrhages.
Observational study.
Fifty-eight eyes of 58 untreated patients with NTG who had at least five reliable visual fields of the Humphrey Field Analyzer (central 30-2) within the follow-up period of more than 24 months were enrolled. Of these, 27 eyes had optic disk hemorrhages in their clinical courses. Pointwise linear regression analysis was done using total deviation values of the fields at each of 74 test locations in each patient. Progression was defined as the points of negative slopes with P <.01. A whole visual field was concentrically divided into three clusters: the areas within 10 degrees, 10 to 20 degrees, and 20 to 30 degrees. Percentages of the progressed points of the three clusters and a whole field were compared between the groups with and without optic disk hemorrhages.
No significant differences were found in patients' backgrounds, including initial mean deviation values, follow-up periods, and the number of visual field examinations between the 27 patients with optic disk hemorrhages and the 31 without. The group with optic disk hemorrhages showed significantly higher percentages of progressed points within the 10-degree area compared with the group without optic disk hemorrhages (mean +/- SD: 13.1 +/- 13.7%; 5.1 +/- 8.5%, respectively; P =.0086, Student t test), whereas no significant differences were found in the other two clusters or in a whole field.
Patients with NTG with optic disk hemorrhages tend to show visual field progression in areas within 10 degrees.
研究患有视盘出血的正常眼压性青光眼（NTG）患者的视野进展特征。
观察性研究。
纳入58例未经治疗的NTG患者的58只眼，这些患者在超过24个月的随访期内至少有5次Humphrey视野分析仪（中央30-2）的可靠视野。其中，27只眼在其临床病程中有视盘出血。对每位患者74个测试位置处视野的总偏差值进行逐点线性回归分析。进展定义为斜率为负且P<.01的点。将整个视野同心划分为三个区域：10度以内区域、10至20度区域和20至30度区域。比较有和无视盘出血组三个区域及整个视野进展点的百分比。
27例有视盘出血的患者与31例无视盘出血的患者在患者背景方面，包括初始平均偏差值、随访期和视野检查次数，均未发现显著差异。有视盘出血组在10度区域内进展点的百分比显著高于无视盘出血组（均值±标准差：分别为13.1±13.7%；5.1±8.5%；P=.0086，Student t检验），而在其他两个区域或整个视野中未发现显著差异。
患有视盘出血的NTG患者倾向于在10度以内区域出现视野进展。
