Peter M E, Krammer P H
The Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA.
Cell Death Differ. 2003 Jan;10(1):26-35. doi: 10.1038/sj.cdd.4401186.
CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.
CD95（APO-1/Fas）是一种典型的死亡受体，其细胞质尾部含有一个80个氨基酸的死亡结构域。该结构域对于在被激动性抗CD95抗体或同源CD95配体激活后招募多种信号传导成分以启动细胞凋亡至关重要。CD95触发后形成的蛋白质复合物称为死亡诱导信号复合物（DISC）。DISC由一种衔接蛋白和起始半胱天冬酶组成，对诱导细胞凋亡至关重要。据报道，许多蛋白质可调节DISC的形成或活性。本综述讨论了死亡受体研究领域的最新进展。
