Lynch H T, Guirgis H A, Brodkey F, Lynch J, Maloney K, Rankin L, Mulcahy G M
Surg Gynecol Obstet. 1976 May;142(5):693-9.
The particular patterns of familial aggregations of cancer in the several families reported from our clinical resource suggest that multiple genotypes explain their diversity of cancer susceptibility. This knowledge could be of value in improving cancer control. We postulate that each particular genotype functions in concert with differential carcinogenic interactions, including a possible oncogenic virus, contributing to carcinogenesis in the susceptible patient. This reasoning is consistent with a concept of genetic heterogeneity as an explanation for familial carcinoma of the breast. This phenomenon is not unlike the current explanation for the genetics of the mucopolysaccaridoses, the lipidoses and several other major disorders of man which show genetic heterogeneity.
从我们的临床资源报告的几个家族中癌症的特定家族聚集模式表明，多种基因型解释了它们癌症易感性的多样性。这一知识对于改善癌症控制可能具有价值。我们推测，每种特定基因型与不同的致癌相互作用协同发挥作用，包括一种可能的致癌病毒，从而导致易感患者发生癌变。这一推理与遗传异质性的概念一致，可作为乳腺家族性癌的一种解释。这种现象与目前对粘多糖贮积症、脂代谢障碍及其他几种显示遗传异质性的人类主要疾病的遗传学解释并无不同。
