El-Domeiri A A, Shroff S
Surg Gynecol Obstet. 1976 May;142(5):722-4.
Although a skeletal scan is an effective means of detecting early metastatic deposits from carcinoma of the breast, its indiscriminate use in screening patients with early tumors does not seem justified because of the low yield of abnormal results. Selection of patients for this procedure should be based on the size of the tumor and the clinical stage of the disease. It is extremely unlikely that patients with a T1 lesion will have an abnormal skeletal scan. A preoperative scan in indicated for T2 lesions in patients with a central or medial quadrant mass, inflammatory carcinoma, palpable axillary lymph nodes or other clinical evidence suggestive of spread beyond breast tissue. All patients with T3 and inoperable tumors should have a bone scan prior to therapy to define the extent of the disease. A routine postoperative scan at six month intervals may be considered only in patients with large primary lesions and involvement of regional lymph nodes.
尽管骨骼扫描是检测乳腺癌早期转移灶的有效手段,但由于异常结果的检出率较低,在早期肿瘤患者筛查中不加选择地使用似乎并不合理。该检查的患者选择应基于肿瘤大小和疾病临床分期。T1期病变患者骨骼扫描结果异常的可能性极小。对于中央或内侧象限肿块、炎性癌、可触及腋窝淋巴结或有其他提示疾病扩散至乳腺组织以外临床证据的T2期病变患者,建议术前行骨骼扫描。所有T3期及不可切除肿瘤患者在治疗前均应进行骨扫描以明确疾病范围。仅对于有大的原发灶和区域淋巴结受累的患者,可考虑每6个月进行一次常规术后扫描。