A new synthesis of cytoxazone and its diastereomers provides key initial SAR information.
作者信息
Carter Percy H, LaPorte Jacob R, Scherle Peggy A, Decicco Carl P
机构信息
Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
出版信息
Bioorg Med Chem Lett. 2003 Apr 7;13(7):1237-9. doi: 10.1016/s0960-894x(03)00131-8.
Abstract
A short, enantioselective, and diastereoselective synthesis of cytoxazone, a Th2-selective immunomodulator from Streptomyces, is described. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Evaluation of these compounds revealed that the stereochemical configuration of the oxazolidinone ring did not influence their biological activity.
摘要
Zotero 插件