Wilson S Brian, Delovitch Terry L
Diabetes Laboratories, Massachusetts General Hospital, 65 Landsdowne Street, Room 525, Cambridge, Massachusetts 02138, USA.
Nat Rev Immunol. 2003 Mar;3(3):211-22. doi: 10.1038/nri1028.
Invariant CD1D-restricted natural killer T (iNKT) cells function during innate and adaptive immunity and regulate numerous immune responses, such as autoimmune disease, tumour surveillance, infectious disease and abortions. However, the molecular basis of their functions and the nature of disease-associated defects of iNKT cells are unclear and have been the subject of recent controversy. Here, we review recent findings that underscore the potential importance of interactions between iNKT cells and dendritic cells (DCs) that indicate that iNKT cells regulate DC activity to shape both pro-inflammatory and tolerogenic immune responses. The ability to modulate iNKT-cell activity in vivo using the ligand alpha-galactosylceramide and to treat patients with autoimmune disease or cancer is evaluated also.
不变自然杀伤T（iNKT）细胞在先天性和适应性免疫过程中发挥作用，并调节多种免疫反应，如自身免疫性疾病、肿瘤监测、传染病和流产。然而，它们功能的分子基础以及iNKT细胞与疾病相关缺陷的本质尚不清楚，并且一直是近期争议的主题。在这里，我们回顾了最近的研究发现，这些发现强调了iNKT细胞与树突状细胞（DC）之间相互作用的潜在重要性，这表明iNKT细胞调节DC活性以塑造促炎和耐受性免疫反应。我们还评估了使用配体α-半乳糖神经酰胺在体内调节iNKT细胞活性以及治疗自身免疫性疾病或癌症患者的能力。
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