Siel Daniela, Beltrán Caroll J, Martínez Eduard, Pino Macarena, Vargas Nazla, Salinas Alexandra, Pérez Oliver, Pereira Ismael, Ramírez-Toloza Galia
Central Veterinary Research Laboratory (LaCIV), Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Santiago 8820808, Chile.
Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370251, Chile.
Animals (Basel). 2022 Jun 27;12(13):1645. doi: 10.3390/ani12131645.
Canine chronic inflammatory enteropathy (CIE) is one of the most common chronic gastrointestinal diseases affecting dogs worldwide. Genetic and environmental factors, as well as intestinal microbiota and dysregulated host immune responses, participate in this multifactorial disease. Despite advances explaining the immunological and molecular mechanisms involved in CIE development, the exact pathogenesis is still unknown. This review compiles the latest reports and advances that describe the main molecular and cellular mechanisms of both the innate and adaptive immune responses involved in canine CIE pathogenesis. Future studies should focus research on the characterization of the immunopathogenesis of canine CIE in order to advance the establishment of biomarkers and molecular targets of diagnostic, prognostic, or therapeutic utility.
犬慢性炎症性肠病（CIE）是全球范围内影响犬类的最常见慢性胃肠疾病之一。遗传和环境因素，以及肠道微生物群和失调的宿主免疫反应，均参与了这种多因素疾病的发生。尽管在解释CIE发病机制中涉及的免疫和分子机制方面取得了进展，但确切的发病机制仍然未知。本综述汇编了最新的报告和进展，这些报告和进展描述了犬CIE发病机制中涉及的先天性和适应性免疫反应的主要分子和细胞机制。未来的研究应集中于犬CIE免疫发病机制的特征研究，以推进具有诊断、预后或治疗效用的生物标志物和分子靶点的建立。
