使用聚-L-谷氨酸表面活性剂衍生物的对映体拆分：空间因素增加的影响。

Enantiomeric separations using polymeric L-glutamate surfactant derivatives: effect of increasing steric factors.

作者信息

Thibodeaux Stefan J, Billiot Eugene, Torres Eric, Valle Bertha C, Warner Isiah M

机构信息

Discovery Chemistry Research and Technologies, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.

出版信息

Electrophoresis. 2003 Mar;24(6):1077-82. doi: 10.1002/elps.200390125.

DOI:10.1002/elps.200390125

PMID:12658698

Abstract

This study examines the role of steric hindrance near the stereogenic centers of four glutamic acid based polymeric surfactants. The single amino acid surfactants of glutamic acid, glutamic acid methyl ester, glutamic ethyl ester, and glutamic acid tert-butyl ester were investigated. The micellar electrokinetic chromatography (MEKC) separation of three binaphthyl derivatives and three benzodiazepines were used to study these steric factors. In addition, the hydrophobicity of these polymers as a function of pH was investigated by use of fluorescence measurements.

摘要

本研究考察了四种基于谷氨酸的聚合物表面活性剂的手性中心附近空间位阻的作用。对谷氨酸、谷氨酸甲酯、谷氨酸乙酯和谷氨酸叔丁酯的单氨基酸表面活性剂进行了研究。采用胶束电动色谱（MEKC）分离三种联萘衍生物和三种苯二氮䓬类化合物来研究这些空间因素。此外，通过荧光测量研究了这些聚合物的疏水性与pH的关系。