p57KIP2在葡萄胎中的低表达及母体特异性表达及其临床意义。

Low and maternal-specific expression of p57KIP2 in hydatidiform mole and its clinical implication.

作者信息

Xiong Yali, Cao Yang, Li Hongfa

机构信息

Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.

出版信息

J Huazhong Univ Sci Technolog Med Sci. 2002;22(2):121-2, 157. doi: 10.1007/BF02857671.

DOI:10.1007/BF02857671

PMID:12658751

Abstract

In situ hybridization was applied to locate and detect the expression of p57KIP2 in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57KIP2 expression were analyzed by HPIAS-1000 Image-Analysis System. p57KIP2 was highly expressed in normal villi but showed distinct low expression in hydatidiform mole (P < 0.01). Furthermore, the locus of low expression of p57KIP2 accorded with the place where lesion of trophoblast occurred. Detection of p57KIP2 made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57KIP2 could be a molecular marker in hydatidiform mole and a target for therapy.

摘要

应用原位杂交技术定位并检测p57KIP2在葡萄胎（5例部分性葡萄胎和18例完全性葡萄胎）及正常绒毛（23例）中的表达。采用HPIAS - 1000图像分析系统分析p57KIP2表达的阳性信号。p57KIP2在正常绒毛中高表达，但在葡萄胎中呈明显低表达（P < 0.01）。此外，p57KIP2低表达的部位与滋养层病变部位相符。检测p57KIP2使得在转录水平研究葡萄胎的遗传学成为可能。p57KIP2低表达可能是葡萄胎的一个分子标志物及治疗靶点。