γδ T细胞的比较生物学
Comparative biology of gamma delta T cells.
作者信息
Chen Zheng W
出版信息
Sci Prog. 2002;85(Pt 4):347-58. doi: 10.3184/003685002783238762.
Abstract
Accumulative evidence suggests that resident gamma delta T cells in epithelia are biologically distinct from systemic gamma delta T cells in the circulation. Murine resident gamma delta T cells have innate immune characteristics and play an important role in tissue homeostasis after damages. In contrast, a unique subset of circulating gamma delta T cells in primates, like alpha beta T cells, can mount adaptive immune responses in infections. This article compares biological features between resident and circulating gamma delta T cells.
摘要
越来越多的证据表明，上皮组织中的驻留γδ T细胞在生物学特性上与循环系统中的系统性γδ T细胞不同。小鼠驻留γδ T细胞具有先天免疫特性，在组织损伤后的组织稳态中发挥重要作用。相比之下，灵长类动物循环γδ T细胞中的一个独特亚群，与αβ T细胞一样，能够在感染中引发适应性免疫反应。本文比较了驻留γδ T细胞和循环γδ T细胞之间的生物学特征。
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