分枝杆菌感染期间Vγ2Vδ2 + T细胞的适应性免疫反应。
Adaptive immune response of Vgamma2Vdelta2+ T cells during mycobacterial infections.
作者信息
Shen Yun, Zhou Dejiang, Qiu Liyou, Lai Xioamin, Simon Meredith, Shen Ling, Kou Zhongchen, Wang Qifan, Jiang Liming, Estep Jim, Hunt Robert, Clagett Michelle, Sehgal Prabhat K, Li Yunyaun, Zeng Xuejun, Morita Craig T, Brenner Michael B, Letvin Norman L, Chen Zheng W
机构信息
Tuberculosis Research Unit, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Science. 2002 Mar 22;295(5563):2255-8. doi: 10.1126/science.1068819.
Abstract
To examine the role of T cell receptor (TCR) in gammadelta T cells in adaptive immunity, a macaque model was used to follow Vgamma2Vdelta2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gammadelta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma2Vdelta2+ T cells were also seen during Mycobacterium tuberculosis infection of naive and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma2Vdelta2+ T cells may contribute to adaptive immunity to mycobacterial infections.
摘要
为了研究γδ T细胞中的T细胞受体（TCR）在适应性免疫中的作用，使用猕猴模型追踪Vγ2Vδ2 + T细胞对分枝杆菌感染的反应。这些磷酸抗抗原特异性γδ T细胞在牛分枝杆菌卡介苗（BCG）感染期间出现大量扩增，并在BCG再次感染后呈现明显的记忆型反应。在未接种疫苗和接种BCG的猕猴感染结核分枝杆菌期间，分别观察到Vγ2Vδ2 + T细胞的初次和再次扩增。这种快速扩增的能力与接种BCG的猕猴中BCG菌血症的清除以及对致命性结核病的免疫相关。因此，Vγ2Vδ2 + T细胞可能有助于对分枝杆菌感染的适应性免疫。
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