Mandelcorn Rochelle, Shear Neil H
Division of Dermatology, Department of Medicine, University of Toronto.
J Am Acad Dermatol. 2003 Apr;48(4):525-9. doi: 10.1067/mjd.2003.107.
Toxic epidermal necrolysis is an acute mucocutaneous reaction characterized by extensive cutaneous and mucosal sloughing and systemic involvement. It is generally associated with drug ingestion.
We describe 2 patients who developed typical clinical and histopathologic features of toxic epidermal necrolysis with unusual subacute progression, absence of systemic involvement or high-risk drug ingestion, and features of lupus erythematosus.
We propose that this constellation of features represents a new entity not previously described. This entity may represent a more severe variant of Rowell's syndrome or, alternatively, a novel manifestation of lupus erythematosus
