Amadian M G, Grabarova M I, Kozhushko I F
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(3):420-2.
The paper deals with the role of hereditary factors in the appearance of epilepsy by the aid of clinical, EEG and biochemical methods. The authors studied 35 children and adolescents with epilepsy and 69 of their relatives. In a EEG study fo the relatives of such patients there were 56% of changed curves, which indicate to an increased readiness of the brain to paroxysmal states. Besides, in the group of relatives where the children had epilepsy of an unknown nature the amount of changed curves was higher than that in the group of relatives where the patients had symptomatical epilepsy (62% and 51%). The biochemical data demonstrated some correlations between the bioelectrical brain activity with an increased amount of isoenzyme and LDH-I in the blood sera of relatives of epileptic patients.
本文借助临床、脑电图和生化方法探讨了遗传因素在癫痫发病中的作用。作者研究了35名癫痫患儿和青少年及其69名亲属。在对这些患者亲属的脑电图研究中，56%的曲线有变化，这表明大脑对发作状态的易感性增加。此外，在儿童患有不明性质癫痫的亲属组中，曲线变化的数量高于患有症状性癫痫患者的亲属组（分别为62%和51%）。生化数据表明，癫痫患者亲属血清中同工酶和LDH-I含量增加与脑生物电活动之间存在一定相关性。
