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Acta Chem Scand B. 1976;30(2):95-100. doi: 10.3891/acta.chem.scand.30b-0095.
The molecular and crystal structure of dextromoramide has been determined by X-ray methods. The crystals are orthorhombic, space group P212121 with unit cell dimensions a = 9.720(4) A; b = 12.226(3) A; c = 18.381(3) A. The structure was determined by direct methods and the model refined to an R-value of 0.036 for 1788 observed reflections. The mean e.s.d.'s in bond lengths and angles are 0.004 A and 0.3, respectively. The morpholine moiety is nearly in antiposition relative to the quaternary carbon atom C6, the pertinent angle C6 - C7 - C9 - N2 being - 159.4. This conformation is similar to that previously reported for the bitartrate of the title compound. The pyrrolidine ring has the envelope conformation and the amide group is strictly planar. The conformation of some acyclic analgetics are discussed.
右吗拉胺的分子和晶体结构已通过X射线方法测定。晶体为正交晶系，空间群P212121，晶胞参数a = 9.720(4) Å；b = 12.226(3) Å；c = 18.381(3) Å。结构通过直接法测定，对1788个观测反射进行精修后R值为0.036。键长和键角的平均标准偏差分别为0.004 Å和0.3。吗啉部分相对于季碳原子C6几乎处于反位，相关角度C6 - C7 - C9 - N2为 - 159.4。这种构象与先前报道的该标题化合物的酒石酸盐的构象相似。吡咯烷环具有信封式构象，酰胺基团严格呈平面状。讨论了一些非环状镇痛药的构象。
