Hovstad L, Lochen E A, Sjaastad O
Acta Neurol Scand. 1976 Feb;53(2):128-36. doi: 10.1111/j.1600-0404.1976.tb04331.x.
Pneumoencephalography was carried out in 23 patients with various muscular disorders, i.e. spinal neurogenic atrophy, classified as Wohlfart-Kugelberg-Welander's and Charcot-Marie-Tooth's diseases, and muscular dystrophy. EEG-registrations and psychological testing were carried out. Pneumoencephalography revealed ventricular enlargement and cortical changes in 17 out of 23 cases. Changes were found in all three groups studied; cortical changes were, however, only found in the neurogenic atrophy groups. Cases where there clearly might be exogenous causes for ventricular dilatation were excluded. The changes found, therefore, supposedly form an integral part of the disease process. It should be emphasized that the precaution does not entirely exclude a traumatic etiology in some cases. EEG-registrations (pathological in three out of 20 cases) as well as psychological evaluation (pathological in six out of 14 cases) supported the assumption of organic brain changes. Pneumoencephalography, however, seemed to be the most sensitive parameter for unveiling brain involvement in these disorders.
对23例患有各种肌肉疾病的患者进行了气脑造影，这些疾病包括脊髓神经源性萎缩（分类为Wohlfart-Kugelberg-Welander病和Charcot-Marie-Tooth病）以及肌肉营养不良。进行了脑电图记录和心理测试。气脑造影显示，23例中有17例出现脑室扩大和皮质改变。在所研究的所有三组中均发现了变化；然而，皮质改变仅在神经源性萎缩组中发现。排除了明显可能存在脑室扩张外部原因的病例。因此，所发现的变化推测是疾病过程的一个组成部分。应当强调的是，这种预防措施并不能在某些情况下完全排除创伤性病因。脑电图记录（20例中有3例异常）以及心理评估（14例中有6例异常）支持了存在器质性脑改变的假设。然而，气脑造影似乎是揭示这些疾病中脑部受累情况最敏感的参数。
