Marttila R J, Rinne U K
Acta Neurol Scand. 1976 Feb;53(2):81-102. doi: 10.1111/j.1600-0404.1976.tb04328.x.
This investigation was conducted to clarify the epidemiology of Parkinson's disease in Finland. A community survey was made in a selected area in southwest Finland in addition to an analysis of Finnish mortality statistics for Parkinson's disease. The annual mortality rate from Parkinson's disease was found to average 2 per 100,000 population. Almost 70 per cent of the deaths occurred between 65-79 years of age. The total and age-specific mortality rates for males were greater than those for females whereas the proportionate mortality rates were almost identical. This was considered to indicate that suggestions of greater male prevalence, based on mortality statistics, do not appear justified. On prevalence day, Dec. 31st, 1971, 484 patients with Parkinson's disease (of which 444 were personally examined) lived in the area of investigation (population 402,988), the prevalence rate being 120.1 per 100,000 population. The highest annual incidence rate was 16.6 per 100,000 population. The age-specific prevalence rates showed a rapid increase after the 50th year of age. The greatest prevalence was shown by the age group 70-79 years of age in which almost 0.8 per cent of the population are affected. Age-specific incidence rates also displayed an increase after the 50th year of age. The greatest incidence was observed in the age group 70-79 years of age in which almost 1 per 1,000 of the population are annually affected by the disease. A difference between the sexes was demonstrable in the prevalence and incidence rates showing greater values for females, but in the age-specific frequencies the differences were reduced. This probably reflects the difference between the age structures of the male and female populations, suggesting that both sexes have a similar risk of being affected by the disease. The permanent age structure shown by idiopathic patients in comparison with previous investigations as well as the increased mean age and proportionate decrease of postencephalitic patients was found to be in disagreement with the cohort theory according to which all parkinsonian patients are previously victims of encephalitis lethargica.
本次调查旨在阐明芬兰帕金森病的流行病学情况。除了分析芬兰帕金森病死亡率统计数据外，还在芬兰西南部一个选定地区进行了社区调查。发现帕金森病的年死亡率平均为每10万人口2例。近70%的死亡发生在65至79岁之间。男性的总死亡率和年龄别死亡率高于女性，而比例死亡率几乎相同。这被认为表明，基于死亡率统计得出的男性患病率更高的说法似乎没有依据。在1971年12月31日患病率调查日，484例帕金森病患者（其中444例接受了个人检查）生活在调查区域（人口402,988），患病率为每10万人口120.1例。最高年发病率为每10万人口16.6例。年龄别患病率在50岁以后迅速上升。患病率最高的是70至79岁年龄组，该组几乎0.8%的人口受影响。年龄别发病率在50岁以后也有所上升。发病率最高的是70至79岁年龄组，该组每年几乎每1000人中有1人受该疾病影响。在患病率和发病率方面，性别差异明显，女性的值更高，但在年龄别频率方面，差异有所减小。这可能反映了男性和女性人口年龄结构的差异，表明两性受该疾病影响的风险相似。与之前的调查相比，特发性患者显示出的固定年龄结构以及平均年龄的增加和脑炎后患者比例的相应下降，与队列理论不一致，根据队列理论，所有帕金森病患者以前都是昏睡性脑炎的受害者。
