用于监测帕金森病神经保护作用的影像学终点指标。

Imaging end points for monitoring neuroprotection in Parkinson's disease.

作者信息

Brooks David J

机构信息

MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom.

出版信息

Ann Neurol. 2003;53 Suppl 3:S110-8; discussion S118-9. doi: 10.1002/ana.10480.

DOI:10.1002/ana.10480

PMID:12666103

Abstract

In this review, the potential role of positron emission tomography and single-photon emission computed tomography as biological markers for following the progression of Parkinson's disease (PD) is discussed, and their value for assessing the efficacy of putative neuroprotective agents in PD is considered. It is concluded that functional imaging provides a valuable adjunct to clinical assessment when judging the efficacy of neuroprotective approaches to PD.

摘要

在本综述中，讨论了正电子发射断层扫描和单光子发射计算机断层扫描作为帕金森病（PD）病情进展生物标志物的潜在作用，并考虑了它们在评估PD中假定神经保护剂疗效方面的价值。得出的结论是，在判断针对PD的神经保护方法的疗效时，功能成像为临床评估提供了有价值的辅助手段。