在不对称催化分子内环丙烷化反应中，烯丙基苯基重氮乙酸酯的对映体控制比较
Comparative enantiocontrol with allyl phenyldiazoacetates in asymmetric catalytic intramolecular cyclopropanation.
作者信息
Doyle Michael P, Hu Wenhao, Weathers Thomas M
机构信息
Department of Chemistry, University of Arizona, Tucson 85721, USA.
出版信息
Chirality. 2003 May 5;15(4):369-73. doi: 10.1002/chir.10219.
PMID:12666246
Abstract
Dirhodium(II) azetidinone-carboxylates are effective asymmetric catalysts for diazo decomposition of allyl diazoacetates and their subsequent intramolecular cyclopropanations. The effect of alkene substituents on enantiocontrol has been examined and modest selectivities have been achieved. Steric influences from substituents on the diazo carbon are seen to diminish enantioselectivities.
摘要
氮杂环丁烷二羧酸铑（II）是烯丙基重氮乙酸酯重氮分解及其随后分子内环丙烷化反应的有效不对称催化剂。已研究了烯烃取代基对对映体控制的影响，并获得了适度的选择性。可以看出，重氮碳上取代基的空间影响会降低对映选择性。
Zotero 插件