[炎症性肠病的发病率和患病率。阿斯图里亚斯5个地区的研究（EIICEA）。西班牙]

[Incidence and prevalence of inflammatory bowel disease. Asturian study in 5 areas (EIICEA). Spain].

作者信息

Saro Gismera C, Riestra Menéndez S, Milla Crespo A, Sánchez Fernández R, Lacort Fernández M, Argüelles Fernández G, Chovac Z, Florido Mancheño J I, Antón Magarzo J L, Altadill Arregui A, Vizoso F, Pineda García E, Fernández de Ocariz Archs E, Albert Colomer J, García Pérez J, López Rivas L, Lombraña J L S

机构信息

Servicio de Aparato Digestivo, Hospital de Cabueñes, Camino de Cabueñes s/n. 33394 Gijón, Asturias.

出版信息

An Med Interna. 2003 Jan;20(1):3-9.

PMID:12666301

Abstract

AIMS

To know and to compare Inflammatory Bowel Disease (IBD) Incidence and Prevalence rates in in five areas of Asturias (Spain). We conducted a prospective epidemiologic study of IBD in the Province of Liege (1 million inhabitants).

PATIENT AND METHODS

We conducted a descriptive, populational, collaborative epidemiologic study, retrospective between 1954 and 1993 and prospective between 1994 and 1997. All patients diagnosed according to a standard protocol for case ascertainment and definition of IBD, aged 14 years or more are included, in five areas of Asturias (Spain) (461,965 inhabitants).

RESULTS

For the period 1954 to 1997, 1018 IBD have been diagnosed [565 ulcerative colitis (UC) (55.5%), 415 Crohn's disease (CD) (40.8%) and 38 undefined IBD (IC) (3.7%)]; [482 women (47.2%), 536 males (52.8%)]. In the 4 year-prospective period, 306 cases were collected: 176 UC (57.51%), 110 CD (35.94) and 20 IC (6.53%); UC/CD: 1.6. Without appreciable and significant differences between Frequency of illness groups and sexes. IBD incidence rate (per 100,000 per year) (1954-97) is 5.12 (95% CI = 3.05-7.18) (UC: 2.84; CD: 2.08; IC: 0.19; UC/CD 1.36). In the 4 years- prospective study, IBD incidence rate is 16.55 (95% CI = 12.84-20.25), (UC: 9.52; CD: 5.95; IC: 1.08; UC/CD: 1.6). IBD prevalence rate in 1997 is 205.21 (95% CI = 182.14-227.29), (UC: 109.96; CD: 87.45; IC: 7.79). Comparisons have settled down among the studied areas, without finding differences statistically significant.

CONCLUSIONS

Inflammatory Bowel Disease incidence and prevalence rates of in our region are homogeneous between the cities investigated and superior than those historically reported in Spanish studies. These results were similar to those observed in European studies.

摘要

目的

了解并比较西班牙阿斯图里亚斯五个地区的炎症性肠病（IBD）发病率和患病率。我们在列日省（100万居民）开展了一项IBD的前瞻性流行病学研究。

患者与方法

我们开展了一项描述性、基于人群的合作性流行病学研究，1954年至1993年为回顾性研究，1994年至1997年为前瞻性研究。纳入了西班牙阿斯图里亚斯五个地区（461,965名居民）中所有根据IBD病例确诊和定义的标准方案确诊、年龄在14岁及以上的患者。

结果

1954年至1997年期间，共确诊1018例IBD [565例溃疡性结肠炎（UC）（55.5%），415例克罗恩病（CD）（40.8%），38例未定型IBD（IC）（3.7%）]；[482名女性（47.2%），536名男性（52.8%）]。在4年的前瞻性研究期间，收集到306例病例：176例UC（57.51%），110例CD（35.94%），20例IC（6.53%）；UC/CD为1.6。疾病组频率和性别之间无明显显著差异。IBD发病率（每年每10万人）（1954 - 97年）为5.12（95%可信区间 = 3.05 - 7.18）（UC：2.84；CD：2.08；IC：0.19；UC/CD 1.36）。在4年的前瞻性研究中，IBD发病率为16.55（95%可信区间 = 12.84 - 20.25），（UC：9.52；CD：5.95；IC：1.08；UC/CD：1.6）。1997年IBD患病率为205.21（95%可信区间 = 182.14 - 227.29），（UC：109.96；CD：87.45；IC：7.79）。各研究地区之间的比较已确定，未发现统计学上的显著差异。