有丝分裂染色体的形成：对经典问题的现代见解

The making of the mitotic chromosome: modern insights into classical questions.

作者信息

Swedlow Jason R, Hirano Tatsuya

机构信息

Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom.

出版信息

Mol Cell. 2003 Mar;11(3):557-69. doi: 10.1016/s1097-2765(03)00103-5.

DOI:10.1016/s1097-2765(03)00103-5

PMID:12667441

Abstract

The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

摘要

有丝分裂染色体的凝聚对于后期姐妹染色单体的准确分离至关重要。一种新出现的观点认为，染色体组装是染色质重组的一个活跃且动态的过程，其中两种ATP水解酶，拓扑异构酶II和凝聚素复合体发挥着核心作用。在这篇综述中，我们讨论了最近的研究工作，这些工作为有丝分裂染色体的分子和结构动力学提供了新的见解。