Chowdhury Abhijit, Santra Amal, Chaudhuri Susmita, Dhali Gopal Krishna, Chaudhuri Sujit, Maity Satya Gopal, Naik Trailokya Nath, Bhattacharya Sujit Kumar, Mazumder Debendra Nath Guha
Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Hepatology. 2003 Apr;37(4):802-9. doi: 10.1053/jhep.2003.50157.
Limited information is available about the prevalence and genotype distribution of hepatitis C virus (HCV) in the general population of India. A community-based epidemiologic study was carried out in a district in West Bengal, India. By a 1:3 sampling method, 3,579 individuals were preselected from 10,737 inhabitants of 9 villages of the district, of whom 2,973 (83.1%) agreed to participate. Twenty-six subjects (0.87%) were HCV antibody positive. The prevalence increased from 0.31% in subjects <10 years of age to 1.85% in those >or=60 years. No difference in prevalence between men and women was observed. Serum alanine aminotransferase (ALT) levels were elevated in 30.8% (8 of 26) of anti-HCV-positive subjects compared with 3.2% (94 of 2,947) anti-HCV-negative subjects (P <.001). HCV RNA was detectable in 80.8% (95% CI, 65.6%-95.91%) of the anti-HCV-positive subjects by reverse transcription-primed polymerase chain reaction (RT-PCR). The participants were HCV types 1b in 2 (9.5%), 3a in 8 (38.1%), 3b in 6 (28.6%), and unclassified in 5 (23.8%). Nucleotide sequencing and phylogenetic analysis assigned the unclassified type to genotype 3e. In conclusion, this study provides general population-based estimates of HCV prevalence, including genotypes, from a South Asian country. Although the prevalence of HCV infection in this population was lower than that reported from industrialized countries of the west, the total reservoir of infection is significant and calls for public health measures, including health education to limit the magnitude of the problem.
关于印度普通人群中丙型肝炎病毒（HCV）的流行情况和基因型分布，现有信息有限。在印度西孟加拉邦的一个地区开展了一项基于社区的流行病学研究。通过1:3抽样方法，从该地区9个村庄的10,737名居民中预先选取了3,579人，其中2,973人（83.1%）同意参与。26名受试者（0.87%）HCV抗体呈阳性。患病率从10岁以下受试者中的0.31%增至60岁及以上受试者中的1.85%。未观察到男女患病率存在差异。抗HCV阳性受试者中30.8%（26例中的8例）血清丙氨酸氨基转移酶（ALT）水平升高，而抗HCV阴性受试者中这一比例为3.2%（2,947例中的94例）（P<.001）。通过逆转录引发聚合酶链反应（RT-PCR），在80.8%（95%CI，65.6%-95.91%）的抗HCV阳性受试者中可检测到HCV RNA。参与者中HCV基因型为1b型的有2例（9.5%），3a型的有8例（38.1%），3b型的有6例（28.6%），未分类的有5例（23.8%）。核苷酸测序和系统发育分析将未分类类型归为3e基因型。总之，本研究提供了一个南亚国家基于普通人群的HCV流行情况估计，包括基因型。尽管该人群中HCV感染的患病率低于西方工业化国家报告的水平，但感染总蓄积量很大，需要采取公共卫生措施，包括开展健康教育以限制问题的严重程度。
