[Effects of salicylate on the capillary permeability of inner ear in guinea pigs].

OBJECTIVE

To further understand the mechanism of salicylate ototoxicity.

METHOD

The capillary permeability of inner ear was compared between the normal group and the salicylate ototoxicity group traced with lanthanum by electron microscopy.

RESULT

The normal inner/outer spiral vessels of basilar membrane, strial blood vessels had no permeability, whereas the capillaries of endolymphatic sac showed a certain permeability. In salicylate ototoxicity group, the permeability of the capillaries mentioned above increased significantly.

CONCLUSION

Salicylate may increase the capillary permeability in inner ear, which may participate in the mechanism of the salicylate ototoxicity.