Rosen Jon, Marschke Keith, Rungta Deepa
Department of Molecular & Cell Biology, Ligand Pharmaceuticals Inc, 10275 Science Center Drive, San Diego, CA 92121, USA.
Curr Opin Drug Discov Devel. 2003 Mar;6(2):224-30.
Nuclear receptors (NRs) are a superfamily of ligand-dependent transcription factors that control diverse aspects of growth, development and homeostasis, making them exciting and important targets for drug discovery. In this review, some of the recent advances in our understanding of NRs, and their application to the discovery of new ligands, will be discussed.
核受体（NRs）是一类依赖配体的转录因子超家族，它们控制着生长、发育和体内平衡的多个方面，这使得它们成为药物研发中令人兴奋且重要的靶点。在本综述中，我们将讨论在理解核受体方面的一些最新进展，以及它们在发现新配体中的应用。
