[地佐环平抑制大鼠下丘脑室旁核中δ-睡眠肽对c-fos基因的抑制作用]
[Dizocilpine inhibits suppression of c-fos gene by delta-sleep peptide in the rat hypothalamic paraventricular nucleus].
作者信息
Umriukhin P E, Anokhin K V, Raevskiĭ K S
机构信息
P. K. Anokhin Research Institute of Normal Physiology, Russian Acad. Med. Sci., Moscow 103009, B. Nikitskaya, 6, Russia.
出版信息
Ross Fiziol Zh Im I M Sechenova. 2003 Jan;89(1):3-7.
PMID:12669586
Abstract
The effects of intracerebroventricular administration of the non-competitive NMDA-receptor blocker Dizocilpine (MK-801) on delta sleep-inducing peptide (DSIP) suppression of c-fos induction, were studied. The data obtained indicate that preliminary i.c.v. MK-801 injection inhibits immediate early gene c-fos suppression by DSIP in the parvocellular paraventricular hypothalamus.
摘要
研究了脑室内注射非竞争性N-甲基-D-天冬氨酸（NMDA）受体阻滞剂地佐环平（MK-801）对δ睡眠诱导肽（DSIP）抑制c-fos诱导的影响。获得的数据表明，预先脑室内注射MK-801可抑制小细胞室旁下核中DSIP对即刻早期基因c-fos的抑制作用。
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