Young Glenn M
Graduate Groups of Microbiology, Food Science, and Biochemistry and Molecular Biology, University of California, Davis, Davis, CA 95616, USA.
Chem Biol. 2003 Mar;10(3):204-5. doi: 10.1016/s1074-5521(03)00052-8.
Type III secretion systems are used by many gram-negative bacterial pathogens of animals and plants to deliver essential virulence factors into targeted host cells. The identification of chemical compounds that block the function of these systems is the first step toward developing chemical attenuation as an effective method for the treatment of infectious disease.
III型分泌系统被许多动植物的革兰氏阴性细菌病原体用来将必需的毒力因子输送到目标宿主细胞中。鉴定能够阻断这些系统功能的化合物是将化学减毒发展成为治疗传染病的有效方法的第一步。
