Gadalla Farida, Lee Sung-Hee Rhim, Choi Kue C, Fong Jill, Gomillion Matthew C, Leighton Barbara L
Department of Anesthesiology, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA.
Can J Anaesth. 2003 Apr;50(4):382-5. doi: 10.1007/BF03021036.
To determine if injecting 10 mL saline before epidural catheter threading (pre-cannulation epidural fluid injection) can decrease the incidence of iv epidural catheter placement during combined spinal-epidural (CSE) labour analgesia.
One hundred healthy women requesting CSE labour analgesia with either fentanyl 20 microg or sufentanil 10 microg were prospectively randomized to receive either no epidural injection (dry group, n = 50) or epidural 10 mL saline injection (saline group, n = 50) before epidural catheter placement. A nylon multiport catheter was then threaded 3-5 cm into the epidural space and the needle was removed. We diagnosed iv catheter placement if blood was freely aspirated, if the mother became tachycardic after injection of epinephrine 15 microg, or if intracardiac air was heard (using ultrasound) after injection of air 1.5 mL.
Intravenous epidural catheter placement occurred in one saline and ten dry group patients (P < 0.01). No complications of excessive cephalad intrathecal opioid spread (i.e., difficulty swallowing, hypoxemia, or respiratory arrest) occurred.
Injecting 10 mL or saline through the epidural needle after intrathecal opioid injection and before threading the catheter significantly decreased accidental venous catheter placement without any apparent increase in complications from excessive cephalad intrathecal opioid spread.
确定在硬膜外导管置入前注射10毫升生理盐水(置管前硬膜外注液)是否能降低腰麻-硬膜外联合(CSE)分娩镇痛期间硬膜外导管误入静脉的发生率。
100例要求行CSE分娩镇痛的健康女性,随机分为两组,一组在硬膜外导管置入前不进行硬膜外注射(干组,n = 50),另一组在硬膜外导管置入前注射10毫升生理盐水(盐水组,n = 50),两组分别使用20微克芬太尼或10微克舒芬太尼。然后将一根尼龙多端口导管置入硬膜外腔3 - 5厘米,拔出穿刺针。若能自由抽出回血、注射15微克肾上腺素后产妇出现心动过速或注射1.5毫升空气后(使用超声)听到心内有空气,则诊断为导管误入静脉。
盐水组有1例、干组有10例发生硬膜外导管误入静脉(P < 0.01)。未出现鞘内阿片类药物向头端过度扩散的并发症(即吞咽困难、低氧血症或呼吸骤停)。
在鞘内注射阿片类药物后、导管置入前,通过硬膜外穿刺针注射10毫升生理盐水可显著降低意外静脉置管的发生率,且未明显增加鞘内阿片类药物向头端过度扩散所致的并发症。