三种不同液体类固醇制剂（泼尼松、泼尼松龙和地塞米松）的口味比较。

A taste comparison of three different liquid steroid preparations: prednisone, prednisolone, and dexamethasone.

作者信息

Mitchell John C, Counselman Francis L

机构信息

Department of Emergency Medicine, Eastern Virginia Medical School and Emergency Physicians of Tidewater, Norfolk, VA, USA.

出版信息

Acad Emerg Med. 2003 Apr;10(4):400-3. doi: 10.1111/j.1553-2712.2003.tb01358.x.

DOI:10.1111/j.1553-2712.2003.tb01358.x

PMID:12670859

Abstract

OBJECTIVES

To determine whether significant differences exist in the taste, texture, smell, and aftertaste of three commonly used liquid steroid preparations: prednisone, prednisolone, and dexamethasone.

METHODS

This was a double-blind study of medical students and residents. Participants were asked to drink 5 mL of each steroid preparation, and grade each on a one-to-five-point scale for the categories of smell, texture, taste, and aftertaste. A score of 5 was considered most positive, 3 neutral, and 1 most negative. The medications were placed in small cups with the letter A, B, or C on them. The steroids were then administered in an advancing alphabetical format. A saltine cracker and water were administered between tastings in an attempt to remove any residual flavor. Data were analyzed using mean score and standard deviations, and mean rank and standard deviation by the Friedman test. Statistical significance was set at p < 0.05.

RESULTS

Eighty-six adult volunteers participated in the study: 53 (62%) were male and 33 were female. The overall mean scores and standard deviations (+/-SDs) for prednisolone, dexamethasone, and prednisone were 3.43 (+/-1.05), 3.19 (+/-1.01), and 2.29 (+/-0.98), respectively. Using the Friedman test, the mean ranks for smell, texture, taste, and aftertaste for dexamethasone were 2.37, 2.06, 2.19, and 2.22. The corresponding mean ranks for prednisone were 1.80, 1.52, 1.31, and 1.27; and for prednisolone, the mean ranks were 1.83, 2.41, 2.51, and 2.52, respectively. Dexamethasone scored better in all four categories than prednisone (p < 0.05). Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell. Dexamethasone had a higher mean rank than prednisolone for smell (p < 0.05); for the remaining three categories, there was no statistical difference.

CONCLUSIONS

In adult volunteers, both prednisolone and dexamethasone liquid were more palatable than prednisone liquid.

摘要

目的

确定三种常用液体类固醇制剂泼尼松、泼尼松龙和地塞米松在味道、质地、气味和余味方面是否存在显著差异。

方法

这是一项针对医学生和住院医师的双盲研究。参与者被要求饮用5毫升每种类固醇制剂，并对气味、质地、味道和余味类别按1至5分进行评分。5分被认为是最积极的，3分为中性，1分为最消极的。药物被放在标有字母A、B或C的小杯子里。然后按照字母顺序递增的方式服用类固醇。在品尝之间给予一块咸饼干和水，以试图去除任何残留的味道。使用平均分和标准差以及通过弗里德曼检验的平均秩和标准差对数据进行分析。统计学显著性设定为p<0.05。

结果

86名成年志愿者参与了该研究：53名（62%）为男性，33名女性。泼尼松龙、地塞米松和泼尼松的总体平均分和标准差（±SD）分别为3.43（±1.05）、3.19（±1.01）和2.29（±0.98）。使用弗里德曼检验，地塞米松在气味、质地、味道和余味方面的平均秩分别为2.37、2.06、2.19和2.22。泼尼松相应的平均秩分别为1.80、1.52、1.31和1.27；泼尼松龙的平均秩分别为1.83、2.41、2.51和2.52。地塞米松在所有四个类别中的得分均高于泼尼松（p<0.05）。泼尼松龙在质地、味道和余味类别中的得分高于泼尼松（p<0.05）；在气味方面没有统计学差异。地塞米松在气味方面的平均秩高于泼尼松龙（p<0.05）；在其余三个类别中，没有统计学差异。