早期检测的理由。

The case for early detection.

作者信息

Etzioni Ruth, Urban Nicole, Ramsey Scott, McIntosh Martin, Schwartz Stephen, Reid Brian, Radich Jerald, Anderson Garnet, Hartwell Leland

机构信息

Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

出版信息

Nat Rev Cancer. 2003 Apr;3(4):243-52. doi: 10.1038/nrc1041.

DOI:10.1038/nrc1041

PMID:12671663

Abstract

Early detection represents one of the most promising approaches to reducing the growing cancer burden. It already has a key role in the management of cervical and breast cancer, and is likely to become more important in the control of colorectal, prostate and lung cancer. Early-detection research has recently been revitalized by the advent of novel molecular technologies that can identify cellular changes at the level of the genome or proteome, but how can we harness these new technologies to develop effective and practical screening tests?

摘要

早期检测是减轻日益增长的癌症负担最具前景的方法之一。它在宫颈癌和乳腺癌的管理中已经发挥了关键作用，并且在结直肠癌、前列腺癌和肺癌的控制中可能会变得更加重要。近年来，新型分子技术的出现使早期检测研究得以复兴，这些技术能够在基因组或蛋白质组水平上识别细胞变化，但是我们如何利用这些新技术来开发有效且实用的筛查测试呢？