在器官培养中，维生素A可促使胚胎哺乳动物皮肤产生纤毛状和分泌性表皮。

Ciliated and secretory epidermis produced from embryonic mammalian skin in organ culture by vitamin A.

作者信息

Sweeny P R, Hardy M H

出版信息

Anat Rec. 1976 May;185(1):93-9. doi: 10.1002/ar.1091850109.

Abstract

When skin from the upper lip of 12-day embryonic mice was grown for ten days in organ culture with 5.7 mug retinol added per ml of biological medium, keratinization was suppressed and a ciliated and secretory epithelium was produced. Ultrastructural features of this epithelium are described. At this very early stage mouse epidermis is thus similar of chick epidermis in its ability to undergo radical metaplasia in response to vitamin A.

摘要

当将12天胚胎小鼠上唇的皮肤在每毫升生物培养基中添加5.7微克视黄醇的器官培养中培养10天时，角质化受到抑制，并产生了纤毛和分泌上皮。描述了这种上皮的超微结构特征。因此，在这个非常早期阶段，小鼠表皮在响应维生素A时发生彻底化生的能力与鸡表皮相似。