Obinata A, Kawada M, Endo H
Dev Biol. 1987 Sep;123(1):59-62. doi: 10.1016/0012-1606(87)90427-1.
Epidermal mucous metaplasia of cultured skin is known to be induced by excess retinol. Studies were made on whether retinol affects primarily the epidermis or the dermis during retinol-induced epidermal mucous metaplasia of 13-day-old chick embryonic skin in culture. When recombinants of 13-day-old normal epidermis and retinol-treated dermis were cultured for 7 days in chemically defined medium in the absence of retinol, hormones, and serum, they showed altered epidermal differentiation toward secretory epithelium (mucous metaplasia). Thus retinol acted primarily on dermal cells.
已知培养皮肤的表皮黏液化生是由过量视黄醇诱导的。针对视黄醇在培养的13日龄鸡胚胎皮肤视黄醇诱导的表皮黏液化生过程中，主要影响表皮还是真皮进行了研究。当13日龄正常表皮与视黄醇处理的真皮的重组体在无视黄醇、激素和血清的化学限定培养基中培养7天时，它们表现出向分泌上皮的表皮分化改变（黏液化生）。因此，视黄醇主要作用于真皮细胞。
