慢性肺组织胞浆菌病伴补体结合滴度下降及痰培养持续阳性。病例报告。

Chronic pulmonary histoplasmosis with declining complement fixation titers and persistence of positive sputum culture. A case report.

作者信息

Fouts J B, Brashear R E, Mandelbaum I, Lampton L M

出版信息

Am Rev Respir Dis. 1976 May;113(5):677-82. doi: 10.1164/arrd.1976.113.5.677.

DOI:10.1164/arrd.1976.113.5.677

Abstract

A patient with culturally proved chronic pulmonary histoplasmosis was treated with amphotericin B. Complement fixation titers decreased but sputum cultures remained positive for Histoplasma capsulatum 5 months after original therapy. Lobectomy and a subsequent course of amphotericin B were necessary. Exceeding the minimal inhibitory concentrations of amphotericin B did not eradicate the organism and declining complement fixation titers failed to have prognostic significance.

摘要

一名经培养证实患有慢性肺组织胞浆菌病的患者接受了两性霉素B治疗。补体结合试验滴度下降，但在初始治疗5个月后，痰培养中荚膜组织胞浆菌仍呈阳性。需要进行肺叶切除术及随后的两性霉素B疗程。超过两性霉素B的最低抑菌浓度并不能根除该病原体，补体结合试验滴度下降也没有预后意义。