Gotoh Naomasa, Murata Takeshi, Ozaki Toru, Kimura Tadashi, Kondo Akiko, Nishino Takeshi
Department of Microbiology, Kyoto Pharmaceutical University, 5 Misasaginakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
J Infect Chemother. 2003 Mar;9(1):101-3. doi: 10.1007/s10156-002-0205-2.
Intrinsic resistance to mureidomycin is shown in Escherichia coli. This is in contrast to Pseudomonas aeruginosa, which generally displays intrinsic resistance to a variety of antimicrobial agents, but not to mureidomycin. Isogenic efflux system mutants from both species were subjected to antibiotic susceptibility tests. These studies showed that the differences regarding the susceptibility of E. coli and P. aeruginosa to mureidomycin A and C may be explained by the expression of efflux systems that mediate resistance to mureidomycin A and C.
大肠杆菌表现出对脲霉素的内在抗性。这与铜绿假单胞菌形成对比，铜绿假单胞菌通常对多种抗菌剂表现出内在抗性，但对脲霉素不具有抗性。对来自这两个物种的同基因外排系统突变体进行了抗生素敏感性测试。这些研究表明，大肠杆菌和铜绿假单胞菌对脲霉素A和C敏感性的差异可能由介导对脲霉素A和C抗性的外排系统的表达来解释。
