Li Yuebin, Lu Hong, Liu Wei, Zhang Chenhui, Xiong Xiaoyan, Xu Shijie, Huang Wei
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200032 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Apr;20(2):123-6.
To disclose the molecular genetic mechanism of type 2 diabetes mellitus and to determine chromosomal location of type 2 diabetes mellitus gene.
Genome-wide screening and genotyping were conducted in a family of type 2 diabetes mellitus, and linkage analysis by LINKAGE and GENEHUNTER package was used to determine the potential chromosomal location of the family of type 2 diabetes mellitus gene.
Evidence of linkage was found at the long arm of chromosome 2. The maximum Lod score is 1.80 and non-parameter Lod score is 5.06.
The type 2 diabetes mellitus gene of the family is located at 2q.
揭示2型糖尿病的分子遗传机制并确定2型糖尿病基因的染色体定位。
对一个2型糖尿病家系进行全基因组筛查和基因分型，采用LINKAGE和GENEHUNTER软件包进行连锁分析，以确定2型糖尿病家系基因的潜在染色体定位。
在2号染色体长臂发现连锁证据。最大Lod值为1.80，非参数Lod值为5.06。
该家系的2型糖尿病基因位于2q。
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